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Backed by Science

Built on the Science of Olive Oil

Olivea was born out of cutting edge research from leading cardiologists & based on human trials published in trusted peer-reviewed medical journals.

Olive Oil & Polyphenol Research
2,000+ Peer-Reviewed StudiesEFSA Authorized Health Claim90,000+ Clinical Participants4x EFSA Daily Threshold

Phenolic compounds from extra virgin olive oil are powerful antioxidants and protect LDL cholesterol from oxidative damage.

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Those in the highest consumption category had 19% lower risk of cardiovascular mortality, 17% lower risk of cancer mortality, 29% lower risk of neurodegenerative mortality.

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Harvard study: High olive oil consumption associated with longevity.

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At least 5 mg of hydroxytyrosol assists in the protection of blood lipids from oxidative stress.

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Olive oil has been proven to lower LDL (bad cholesterol) and raise HDL (good cholesterol).

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Extra virgin olive oil also reduces the risk of heart attacks.

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What the Research Found

What Hydroxytyrosol Does for Your Body

Heart Health

This is the benefit with the strongest regulatory backing. The European Food Safety Authority (EFSA) reviewed the evidence and approved a specific health claim: olive oil polyphenols like hydroxytyrosol contribute to the protection of blood lipids from oxidative stress. In a landmark clinical trial (Covas et al., 2006), people who consumed high-polyphenol olive oil saw their "good" HDL cholesterol rise while their oxidized "bad" LDL dropped.

Studies also show hydroxytyrosol supports healthy blood vessel function and helps maintain normal blood flow, both important for long-term cardiovascular wellness.

EFSA
The EFSA-Approved Olive Polyphenol Health Claim
↑ HDL
Increased Good Cholesterol
↓ oxLDL
Reduced Oxidized LDL
5mg
Daily EFSA Threshold

Brain Health

One of the most promising findings is that hydroxytyrosol (or compounds it breaks down into) can actually reach the brain. Studies show olive polyphenols including HT help protect brain tissue from oxidative injury, and Zheng et al. (2015) found that HT supplementation improved neurogenesis and cognitive function via Nrf2/BDNF pathways.

Researchers have also found it may reduce brain inflammation and guard against the toxic protein buildup associated with age-related cognitive decline.

CNS
Metabolites Detected in Brain
Nrf2
Pathway Activation
↓ Aβ
Amyloid Beta Toxicity
BBB
Blood-Brain Barrier Crossing

Cellular Protection

Most antioxidants work by neutralizing free radicals directly. Hydroxytyrosol goes a step further: it flips on your body's own antioxidant system. It activates a cellular switch called Nrf2, which tells your cells to produce more of their built-in protective enzymes like glutathione.

It also supports your mitochondria, the parts of your cells that generate energy. By reducing oxidative stress at this level, hydroxytyrosol helps keep your cells functioning efficiently as you age.

Nrf2
Master Antioxidant Switch
↑ GSH
Glutathione Production
↑ SOD
Superoxide Dismutase
↓ ROS
Free Radical Reduction

Inflammation Support

Chronic, low-grade inflammation is now considered a root driver of many modern health problems. Hydroxytyrosol helps by dialing down the body's inflammatory signals at the source. Richard et al. (2011) showed that hydroxytyrosol measurably reduced key inflammatory markers in immune cells.

It works alongside oleocanthal, another olive polyphenol found naturally in EVOO, which researchers found has a mechanism similar to ibuprofen (Beauchamp et al., 2005). Together, they offer complementary support for a healthy inflammatory response.

NF-κB
Pathway Inhibition
↓ TNF-α
Pro-Inflammatory Cytokine
↓ IL-6
Inflammation Marker
COX
Oleocanthal Synergy

Metabolic Health

Research suggests hydroxytyrosol may support healthy blood sugar balance. de Bock et al. (2013) found that overweight men who took olive leaf polyphenols showed improved insulin sensitivity, meaning their bodies became more efficient at processing blood sugar.

Lab studies also show it activates AMPK, an enzyme sometimes called the body's "metabolic master switch" because it helps regulate how cells use energy.

AMPK
Metabolic Switch Activation
↑ Insulin
Insulin Sensitivity
↓ Fat
Hepatic Fat
Glucose
Metabolism Support

Skin & Light Protection

D'Angelo et al. (2005) showed that hydroxytyrosol helps protect skin cells from UV-induced oxidative damage, and additional research supports its role in natural collagen production and maintaining an even skin tone.

It also helps reduce the activity of enzymes (called MMPs) that break down collagen as you age. Avola et al. (2019) showed HT prevents blue-light-induced MMP elevation and preserves collagen integrity in skin cells.

UV
Photoprotection
↓ MMP
Collagen Preservation
↑ Type I
Collagen Synthesis
Shield
Dermal Protection

Healthy Aging

Aging is driven by the gradual accumulation of oxidative damage to DNA, proteins, and lipids, compounded by chronic low-grade inflammation. Hydroxytyrosol targets both sides simultaneously: it reduces oxidative damage while dialing down inflammatory signaling.

A 2025 randomized controlled trial showed that 15 mg/day of hydroxytyrosol for 16 weeks significantly reduced DNA damage, protein oxidation, and inflammation markers — the exact biomarkers that deteriorate with age.

↓ 8-OHdG
DNA Damage Marker
↓ Carbonyls
Protein Oxidation
↑ GPx
Antioxidant Defense
↑ TAS
Total Antioxidant Status
How Olivea Delivers It

Capsule-in-Capsule Technology

Most supplements use dry powder. Olivea's dual-capsule design keeps hydroxytyrosol in its natural oil-based matrix for superior absorption.

HT OUTER CAPSULE 400 mg Extra Virgin Olive Oil INNER CAPSULE 200 mg Olive Extract Powder 20 mg Hydroxytyrosol STANDARDIZED TO 10% HT 4x the EFSA daily threshold (5 mg)
Capsule-in-Capsule Technology

Most supplements use dry powder. Olivea’s inner capsule contains 200 mg of olive extract powder standardized to 20 mg hydroxytyrosol, surrounded by an outer capsule filled with 400 mg of real extra virgin olive oil. This keeps the molecule in its natural amphipathic environment, so it absorbs properly in both water and fat phases.

Oil-based matrix Superior bioavailability Freshness-sealed
Our Advisors

Science Advisory Board

Olivea's formulation is guided by leading researchers in cardiovascular health, nutrition science, and polyphenol biochemistry.

Dr. Constantine Tarabanis
Dr. Constantine Tarabanis
Medical Advisor
Dr. Tarabanis graduated from Harvard College, before earning a medical degree from Harvard Medical School, and is a board-certified internist. Now a cardiology fellow at Mass General Brigham-Harvard Medical School, his research spans drug development, vascular tissue engineering, and AI applications in cardiology.
Dr. Joel Kahn
Dr. Joel Kahn
Medical Advisor
Dr. Kahn earned his BA and MD from the University of Michigan, and is a board-certified cardiologist. A Clinical Professor of Medicine at Wayne State University and founder of the Kahn Center for Cardiac Longevity, he is a Fellow of the American College of Cardiology whose work spans preventive cardiology, plant-based nutrition, and vascular health.
Dr. Stephen Anton, PhD
Dr. Stephen Anton, PhD
Medical Advisor
Dr. Anton serves as a Professor at University of Florida's Department of Physiology and Aging. With over 200 published studies in top medical journals, Dr. Anton is a leading researcher on how diet, exercise, and fasting affect the biology of aging. His nationally recognized work focuses on how lifestyle and natural compounds including the polyphenols in olive oil, can protect against obesity, cardiovascular disease, and metabolic decline.
Iliana Flessa
Iliana Flessa
R&D Advisor
Iliana Flessa is a certified olive oil taster based in Kalamata, Greece, in the heart of Messinia's olive country. With over a decade of experience leading quality assurance at Olymp, she oversees Olivea's chemical analysis, polyphenol testing, and sensory evaluation to ensure every batch meets world-class standards.
Proof of Potency

Third-Party Lab Results

Every batch independently tested by ISO 17025-accredited labs. Potency, purity, and safety — published in full.

23.54 mg
hydroxytyrosol per capsule — 17.7% above label claim
View Full Certificate of Analysis →
Potency
✓ 23.54 mg HT/capsule
HPLC verified. Exceeds 20 mg label claim.
Purity
✓ All heavy metals clear
As, Cd, Pb, Hg — well below FDA limits.
Safety
✓ All pathogens absent
Full 8-organism microbial panel clear.

The Science Is In The Capsule

20 mg hydroxytyrosol per capsule. 4x the EFSA threshold. Backed by 2,000+ studies.

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